Evidence-based Approaches to Implementing Biosafety in Diagnostic and Research Laboratories

Welcome to the Elizabeth R. Griffin Foundation's groundbreaking project! In the midst of the global pandemic, laboratories worldwide were under immense pressure to carry out diagnostic testing and expand research on coronaviruses. Recognizing the critical role these laboratories play, we are embarking on an initiative to examine and enhance biosafety practices.

Our project focuses on evaluating the implementation and effectiveness of the World Health Organization's risk-based biosafety guidelines, as well as the laboratory sustainability initiative of the World Organization for Animal Health. By conducting basic research in operational contexts, we aim to provide invaluable insights into the application of these guidelines.

Working closely with key laboratories in priority countries, our project will deliver evidence-based recommendations for implementing biosafety guidelines. We will undertake a comprehensive biorisk assessment of each laboratory, develop collaborative research strategies with specific objectives, and create experimental plans and Standard Operating Procedures (SOPs) to test these objectives.

Through meticulous analysis and findings, we will refine and update the SOPs and guidance documents, ensuring they are optimized for real-world use. The culmination of our efforts will be the publication of our research in a prestigious, peer-reviewed journal, sharing our results with the wider scientific community.

At the Elizabeth R. Griffin Foundation, we believe in the power of knowledge sharing. As part of our commitment to accessibility, comprehensive guidance documents will be freely available for download on our website. These resources will be provided in multiple languages, including English, French, Arabic, and Spanish, facilitating global collaboration and information exchange.

Join us in advancing laboratory biosafety practices and preventing valuable experiences from being lost amidst the pandemic's chaos. Together, we can support the adoption of WHO's and WOAH’s risk-based approach and foster a stronger, more resilient scientific community.

Collaborators

  • Represented Country: Benin

    Project Title: A Survey of Biosafety and Biosecurity Practices in public and private medical and veterinary laboratories in Benin

    Dr. Philippe Sessou is a Lecturer-Researcher, Associate Professor at the Polytechnic School of Abomey-Calavi, University of Abomey-Calavi in Benin Republic. He holds an engineering degree in Animal Health and Production and a PhD in Food and Industrial Microbiology. He is a former Head of Animal Health and Production Department in his institution and the National Coordinator of the International citizen project that assessed adherence to public health measures and their impact on the COVID-19 outbreak. He is the current coordinator of research group “Food Safety and Sustainable Animal Productions) in the Research Unit on Communicable Diseases. He obtained several opportunities where he held a Postdoctoral Fellowship position in India for more than five months at Microbial Resources Division in the Institute of Bioresources and Sustainable Development.

    Doctor Philippe Sessou research activities can be divided into four main areas:

    1. Management and Control of pandemics and neglected zoonoses namely COVID-19, Rabies, Tuberculosis, Toxoplasmosis.

    2. Food safety especially for milk and milk products.

    3. Antimicrobial resistance among humans and animals especially pets.

    4. Exploration of antimicrobial activities of plant extracts to fight against pathogens in farm production and human healthy and food safety. He has published more than forty articles in indexed journals with an impact factor.

    To contribute to the achievement of sustainable development goals, particularly the one related to the resolution of health problems, Dr. Sessou is resolutely committed to the fight against current and future pandemics.

  • Represented Country: Nigeria

    Project Title: Assessment of biosafety measures and training workshop on biosafety management and proper waste disposal among laboratory health staff in Yola Adamawa State, North-eastern Nigeria

    Dr. Chuchan Glenn is a veterinarian from Gombi Local Government area of Adamawa State north-eastern Nigeria. She started her secondary education at Bayero University Staff Secondary School Kano and her tertiary education in university of Maiduguri, Borno State where she obtain her Doctor of Veterinary Medicine (DVM). She completed the National Youth Service Corps in Gombe State North-eastern Nigeria. Upon graduation, she started working with the Adamawa state government as a veterinary officer and rose to the rank of a principal veterinary officer till date. She obtained a post graduate Diploma from the National open university of Nigeria. Her affiliations includes, Veterinary council of Nigeria (VCN), Nigerian Veterinary Medical Association (NVMA) and the Nigerian biological safety association.

  • Represented Country: Uganda

    Project Title: Adoption, Compliance and Effectiveness of WHO-recommended BioSafety​ Practices and Guidelines at Public Health Laboratories in Central Uganda

    Harriet joined MUWRP as a Laboratory Technologist in 2010. She first worked in Bundibugyo district to establish a laboratory to support the MUWRP research: (Long-term sequelae after Ebola virus disease in Bundibugyo, Uganda: a retrospective cohort study: PMID: 25910637), which was to generate data on the long term effects of Ebolavirus to confirmed survivors of Ebola after the 2007 outbreak.

    The assignment, initially planned for six months, was accomplished in a record of 4! Due to this excellent performance, Harriet was voted as the department employee of the year 2010. She then joined the MUWRP College of American Pathologists’ (CAP) accredited laboratory in Kampala and obtained competency in specimen processing, clinical chemistry, hematology, flow cytometry and serological assays.

    She also volunteered as the lab safety officer, a position she ran concurrently with her main duties. In this position, she ensured the lab’s biosafety practices were maintained, and conducted annual biosafety trainings for lab staff while mentoring MUWRP affiliates in biosafety practices.

    In 2011, she was promoted to head the Flow Cytometry section, leading performance of assays like Immune Activation, and Intracellular Cytokine Staining.

    In 2016, Harriet was promoted to the position of Quality Assurance and Quality Control officer, a position she currently holds. Herein, she supports the laboratory to maintain its accreditation and also participates in Quality Management System mentorship programs.

  • Represented Country: United States of America

    Project Title: Validating inactivation procedures for biosafety level 4 (BSL-4) viruses for research purposes

    Dr. Elke Mühlberger is an expert in the field of biosafety level 4 (BSL-4) viruses. She has a strong research focus on the highly pathogenic filoviruses, including Ebola and Marburg viruses. Her research interests range from filoviral replication and transcription strategies to host response mechanisms in filovirus infection. The Mühlberger lab pursues a highly cross disciplinary approach and collaborates with experts in distinct research areas, including tissue engineering, fluid dynamics, omics studies, and RNA biology.

    The NEIDL at Boston University is a 195,000 sq. ft. research facility that houses BSL-4, BSL-3, and BSL-2 laboratories as well as administrative and operational support spaces. The NEIDL is organized as an NIH center with research support and infrastructure operations cores, enabling research on NIAID category A category A, B and C priority agents. Work in the NEIDL includes basic, translational, and clinical research at all biosafety levels with a focus on emerging and re-emerging infectious diseases.

    Dr Mühlberger is the Director of the BSL-4 Integrated Science Core of the NEIDL, which includes the Virology Services Core (VSC). VSC is responsible for the propagation, purification, verification, and safe storage of BSL-4 agents. BSL-4 pathogens propagated in the core include Nipah, Hendra, Ebola, Marburg, Lassa, and Crimean-Congo hemorrhagic fever viruses. VSC also validates inactivation procedures, develops the respective inactivation protocols, and provides inactivated material from BSL-4 pathogens which can be used as samples for research purposes and antigens for antibody production. Furthermore, VSC assists projects in screening antiviral compounds, conducting next generation sequencing analyses, and investigating mechanisms of pathogenesis by performing the necessary BSL-4 cell culture infection studies. Finally, VSC provides the infrastructure and necessary training to facilitate self-use of core equipment by NEIDL investigators.

  • Represented Country: Morocco

    Project Title: Test and Evaluate the performance of WHO Laboratory Biosafety Manual fourth edition​ at Pasteur Institute of Morocco

    Dr. Mohammed ABID, a distinguished scientist and the Head of the Research Department at the Pasteur Institute of Morocco in Tangier, has dedicated his illustrious career to the study of infectious diseases and the development of molecular biology diagnosis tools. His journey in the field of microbiology and epidemiology has left an indelible mark on the scientific community.

    Dr. Mohammed's research at the Pasteur Institute of Morocco has spanned various critical areas, showcasing his commitment to public health. Notably, he conducted groundbreaking work on HIV-1 molecular epidemiology, shedding light on the dynamics of HIV infection in Morocco. Additionally, he delved into the molecular intricacies of tuberculosis strains in the country, elucidating their genetic diversity and impact on public health. His exploration extended to the correlation between immigration and tuberculosis epidemiology, a study of paramount importance in a globalized world.

    Beyond these pursuits, Dr. Mohammed delved into the realm of foodborne pathogens, examining the prevalence and characteristics of Staphylococcus aureus and Salmonella species, which play a significant role in food safety. His tireless efforts and research acumen have been instrumental in fortifying the scientific foundation of the Pasteur Institute of Morocco.

    Dr. Mohammed's contributions extend far beyond the confines of a laboratory. His involvement in high containment laboratories, dating back to 1995, demonstrates his unwavering dedication to tackling highly virulent pathogens. He stands as a pioneer in characterizing Moroccan HIV-1 strains and illuminating the epidemiology of HIV-1 infection within Morocco, providing vital insights for public health policy and intervention strategies.

    Upon joining the Pasteur Institute of Morocco in Tangier in 2002, Dr. Mohammed shouldered the immense responsibility of establishing a research department focused on infectious diseases. Since 2004, his roles have expanded to include heading the Genetic Mycobacteria Laboratory, imparting his knowledge through teaching, organizing essential meetings and training programs, and managing critical research projects on infectious diseases in collaboration with international institutions.

    His leadership extends beyond the confines of the laboratory and academic halls. Dr. Mohammed has championed biosafety, biosecurity, and biorisk management, demonstrating a profound commitment to the wellbeing of both researchers and the public. His engagement in various projects and collaborations, including the UNICRI project and the Moroccan CBRN team, exemplifies his dedication to safety and security in the realm of infectious diseases.

    Dr. Mohammed's journey towards expertise in biosecurity and biosafety has been commendable. His certifications from IFBA and CDC Africa as a Biosafety and Biosecurity Risk Management (BRM) professional and a high containment laboratories trainer respectively, attest to his commitment to global health security.

External ERGP Biosafety Expert Committee

  • James M. “Jim” Welch, a native of Kingsport, Tennessee, Jim Welch served 19 years as the executive director of the Elizabeth R Griffin Research Foundation, a US-based non-profit organization that worked nationally and globally fostering global health security. Upon his retirement in 2018, the Foundation was transitioned to becoming the Elizabeth R Griffin Program at the Center of Global Health Science and Security at Georgetown University Medical School.

    Jim was the originating chair of the US steering group of the Global Health Security Agenda Consortium (GHSAC) and was the first NGO member of the Global Health Security Agenda Steering Group. Among his professional activities, he has been a member of the OIE Consultation Group on Sustainable Biosafety and Biosecurity, the advisory board of the National Biosafety and Biocontainment Training Program at the US National Institutes of Health, the global councils of the International Federation of Biosafety Associations (IFBA), ABSA International, and the Law Enforcement and Veterinary International Conference at INTERPOL.

    He was the 2011 recipient of the John H Richardson Award of ABSA International and is an honorary member of the Association of Primate Veterinarians and the International Veterinary Biosafety Working Group. He was named a Rotary International Paul Harris Fellow in 2022 and is a former president of the Kingsport, Tennessee Board of Education. He has been a key speaker, instructor, moderator and panelist at professional and governmental conferences, seminars, leadership programs, universities and for private companies around the world.

  • Ms. Sacha Wallace-Sankarsingh, MSc, MPH (International Public Health), is an international health security laboratory consultant working with public health institutions to address issues of biosafety and biosecurity in the Caribbean. A national of Guyana, Ms. Wallace-Sankarsingh has over 15 years of experience working with medical and public health laboratories at national and regional levels in the Caribbean Community (CARICOM). Her initial training was in Immunology of Infectious Diseases; however, Sacha has spent most of her career implementing laboratory quality systems following applicable international standards and promoting biosafety and biosecurity best practices. Sacha is best known for her contributions as the Biorisk Manager of the Caribbean Public Health Agency (CARPHA), located in Port-of-Spain, Trinidad, and Tobago. In this role, she managed the biosafety and biosecurity program in the CARPHA Medical Microbiology Laboratory (CMML) Biosafety Level 2 and 3 laboratories, initiated the regional network of National Focal Points, Biosafety and Biosecurity and in recent years held a guiding role as the Caribbean Public Health Laboratory Network (CariPHLN) Manager.

    Sacha focuses much of her work on the small island developing states of the Caribbean, while at the international level, Ms. Wallace-Sankarsingh has been an advocate for strengthening national biosafety systems as a pillar of health security: as the 2020 – 2021 Chair of the Global Health Security Agenda’s Action Package Prevent 3 (APP3) on Biosafety and Biosecurity; Board member of the International Federation of Biosafety Associations (IFBA) and involved in various initiatives including the Global Partnership’s Signature Initiative with the Africa CDC; NTI-Bio’s Global Biosecurity Dialogue; Chatham House’s Sustainable Laboratories Initiative and the new WHO Technical Advisory Group on Biosafety (WHO TAG-B).

  • Dr. Halima Benbouza received her doctorate in agronomic sciences and biological engineering from Agro Bio Tech Gembloux, Belgium studying plant breeding and Genetics and was offered a postdoctoral position to work with the ARS-US-DA. From 2010-2016, she served as Founder and C&O Director of the National Biotechnology Research Center (CRBt). She was President of the Intersectoral Commission of Health and Life Sciences. Pr. Benbouza is a past member the Sectorial Permanent Board of the Ministry of Higher Education and Scientific Research.

    In 2014, she was honored by the US Embassy, Algiers, as one of the “Women in Science Hall of Fame”, and was chosen as one of the 6 best African Women Scientists by the "Next Einstein Forum”. She was appointed representative of Algeria to UNESCO IGCB (2015-2019). In 2017, she served on the Committee on Regional Workshops on Science and Technology Issues for the Biological Weapons Convention, convened by the US National Academies of Sciences, Engineering and Medicine. Pr. Benbouza serves as member of the Executive Committee, Pan African Congress of Ethics and Bioethics (COPAB) since 2015.

    In 2020 , she was selected to be a member of the national commission of ethics and deontology at the Ministry of Higher Education and National Research.

    Pr. Benbouza consults for a number of international organizations on biosafety and biosecurity education and serves as research reviewer on various international scientific panels. Currently, she is Director at the National Council of Scientific Research and Technologies.

  • Dr. Djibril SANGARE is a PhD holder in Medical Entomology and parasitology (University Of Mali, Bamako Mali). He also is a PhD holder in Molecular entomology (University of Notre Dame, Indiana, and USA) and is working at the Malaria Research and Training Center (MRTC) in Bamako, Mali as senior scientist researcher. He was the head of the malaria Vector bioinformatics, and currently leading Vector Immunity and molecular entomology Units. As lecturer he is associate Professor teaching Cell and molecular Biology at the Faculty of Medicine and directly involved in the training of students for their thesis/dissertations in medical Entomology/parasitology.

    Actually, I am the president of the Malian Association for Biosafety and Biosecurity which primary mission include Training in Biosafety and Biosecurity of life scientists working on Public Health, Animal Health, agriculture; Diagnosis, Research, and Education: -Involving investigation on Biosafety and Biosecurity issues in different laboratories Biosafety and Biosecurity levels in Mali. -Development of tools, guidelines and regulation to inform and educate laboratories’ staff, health services agents & users on Biorisk.

  • Dr. Zalini binti Yunus is the Deputy Director General of the Science and Technology Research Institute for Defence (STRIDE), Ministry of Defence Malaysia. Dr. Zalini also served as the National Contact Point for the Biological and Toxin Weapons Convention (BTWC). She has continuously work with national stakeholders in strengthening national measures to fulfil Malaysia’s obligations to the BTWC especially in capacity building programs in biosecurity, biorisk management and inter-sectoral coordination in deliberate bio-incidents’ response and joint investigations.

    In addition, she has served as a member of the World Health Organization's (WHO) Roster of Experts in Biosafety, Biosecurity and Biorisk Management. At the national level, she has served as the Chair of the Technical Committee for Drafting of Malaysia’s Biological and Toxin Weapons Convention (BTWC) Bill and Regulations, Chair of the Policy Development Committee for the National Policy on BTWC Implementation and the lead editor for Malaysia's Biological Incident Emergency Response and investigation Guide. She is currently the Chair of STRIDE’s R&D Roadmap Development Committee and the Chair of STRIDE and Malaysian Armed Forces Engagement Program on Defence S&T Expertise and Capabilities.

    She graduated with a degree in Microbiology from National University of Malaysia, obtained her Master of Science in Immunology and Allergy from the University of Nottingham, United Kingdom, and received her PhD in Chemical Engineering from the University of Manchester, Institute of Science and Technology (UMIST), United Kingdom.

  • Geoffrey Otim is a seasoned molecular biologist with extensive experiences and interests in synthetic biology and biosecurity. With strong passion for these fields, he honed his skills through a two (2) times Biosecurity fellowship program sponsored by the Johns Hopkins Center for Health Security.

    As a leading voice in the synthetic biology and biosecurity communities in Africa, Geoffrey has founded the first iGEM team from East Africa, organized the first international synthetic biology and biosecurity conference in Africa, and led the first stakeholders-focused pandemic preparedness and response initiative in Africa (SynBio Africa Global Catastrophic Biological Risks Initiative). He has received many awards, fellowships, and invitations to speak at international conferences. His current areas of research interest focuses on the discovery of cryptic microbial secondary metabolites from biodiversity through synthetic biology, and the utilization of the available biomass streams in the production of useful energy products such as ethanol, butanol, and methane.

    Geoffrey studied an MSc in Molecular Biology and Biotechnology from Makerere University, a BSc in Medical Laboratory Science from Mbarara University, an Advanced Diploma in Health Management and Leadership from the Uganda Institute of Allied Health and Management Sciences, and a master's degree in International Affairs and Diplomacy from the University of Catalunya/UNITAR. He also did professional development advanced short courses in synthetic biology from the Cold Spring Harbor Laboratory, and science policy & Advocacy for STEM scientists from University of California, Irvine.

    With his diverse background, cutting-edge research, and passion for making a difference, Geoffrey is a valuable asset for any organization in the fields of synthetic biology, biosafety and biosecurity.

  • Irma. R. Makalinao, MD. Professor and Graduate Program Adviser. Department of Pharmacology and Toxicology. College of Medicine. University of the Philippines Manila.

Resource Library

  • Coming Soon

  • Coming Soon

  • Coming Soon

  • Coming Soon

Project Updates Coming Soon